Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network NAPQI Wikipedia g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Kantify Improving Human Health through Artificial Intelligence Metabolism of Paracetamol (Acetaminophen), Acetanilide and Phenacetin Medicinal Chemistry PharmaXChange.info Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.